Peer-reviewed veterinary case report
Changes in gut lining bacteria in dogs with chronic bowel disease
By Cassmann, Eric et al.·Published in PloS one·2016·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Alterations of the Ileal and Colonic Mucosal Microbiota in Canine Chronic Enteropathies.
- Species:
- dog
Plain-English summary
A group of dogs with chronic intestinal issues, like inflammatory bowel disease (IBD) and granulomatous colitis, were found to have an imbalance in their gut bacteria compared to healthy dogs. The study showed that dogs with these conditions had higher levels of certain harmful bacteria, including E. coli, which were found attached to their intestinal lining. This suggests that the gut microbiota plays a significant role in the severity of their symptoms. Understanding these bacterial changes can help veterinarians develop better treatment plans for dogs suffering from chronic enteropathies.
People also search for: dog chronic diarrhea treatment · dog inflammatory bowel disease symptoms · E. coli in dogs gut health
Abstract
BACKGROUND: The intestinal microbiota is increasingly linked to the pathogenesis of chronic enteropathies (CE) in dogs. While imbalances in duodenal and fecal microbial communities have been associated with mucosal inflammation, relatively little is known about alterations in mucosal bacteria seen with CE involving the ileum and colon. AIM: To investigate the composition and spatial organization of mucosal microbiota in dogs with CE and controls. METHODS: Tissue sections from endoscopic biopsies of the ileum and colon from 19 dogs with inflammatory bowel disease (IBD), 6 dogs with granulomatous colitis (GC), 12 dogs with intestinal neoplasia, and 15 controls were studied by fluorescence in situ hybridization (FISH) on a quantifiable basis. RESULTS: The ileal and colonic mucosa of healthy dogs and dogs with CE is predominantly colonized by bacteria localized to free and adherent mucus compartments. CE dogs harbored more (P < 0.05) mucosal bacteria belonging to the Clostridium-coccoides/Eubacterium rectale group, Bacteroides, Enterobacteriaceae, and Escherichia coli versus controls. Within the CE group, IBD dogs had increased (P < 0.05) Enterobacteriaceae and E. coli bacteria attached onto surface epithelia or invading within the intestinal mucosa. Bacterial invasion with E. coli was observed in the ileal and colonic mucosa of dogs with GC (P < 0.05). Dogs with intestinal neoplasia had increased (P < 0.05) adherent (total bacteria, Enterobacteriaceae, E. coli) and invasive (Enterobacteriaceae, E. coli, and Bacteroides) bacteria in biopsy specimens. Increased numbers of total bacteria adherent to the colonic mucosa were associated with clinical disease severity in IBD dogs (P < 0.05). CONCLUSION: Pathogenic events in canine CE are associated with different populations of the ileal and colonic mucosal microbiota.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26840462/