Peer-reviewed veterinary case report
Altered brain myelin sheath morphology after rewarming in situ.
- Journal:
- Ultrastructural pathology
- Year:
- 2010
- Authors:
- Dietrichs, E S et al.
- Affiliation:
- Department of Anesthesiology
- Species:
- rodent
Abstract
In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (15-13 degrees C). Animals held at 37 degrees C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantified by morphometry. Serum analysis of the stress marker S-100beta was carried out in identical groups. The most striking findings in rewarmed animals, when compared to controls, were alterations of myelin sheaths (p<.008) and elevated S-100beta (p<.0001). This indicates that cells in the central nervous system are susceptible to injury in an experimental model of accidental hypothermia and rewarming.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20192705/