Peer-reviewed veterinary case report
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
- Journal:
- Human molecular genetics
- Year:
- 2011
- Authors:
- Singaraja, Roshni R et al.
- Affiliation:
- Centre for Molecular Medicine and Therapeutics and Child and Family Research Institute · Canada
- Species:
- rodent
Abstract
Huntingtin interacting protein 14 (HIP14, ZDHHC17) is a huntingtin (HTT) interacting protein with palmitoyl transferase activity. In order to interrogate the function of Hip14, we generated mice with disruption in their Hip14 gene. Hip14-/- mice displayed behavioral, biochemical and neuropathological defects that are reminiscent of Huntington disease (HD). Palmitoylation of other HIP14 substrates, but not Htt, was reduced in the Hip14-/- mice. Hip14 is dysfunctional in the presence of mutant htt in the YAC128 mouse model of HD, suggesting that altered palmitoylation mediated by HIP14 may contribute to HD.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21775500/