Peer-reviewed veterinary case report
Changes in blood immune proteins in dogs with atopic dermatitis
By Mazrier, Hamutal et al.·Published in Veterinary dermatology·2022·Sydney School of Veterinary Science, Australia·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Altered plasma cytokines in dogs with atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy condition) showed higher levels of certain immune proteins in their blood compared to healthy dogs. Specifically, dogs with this condition had increased amounts of cytokines like IL-7 and IL-15, which are linked to inflammation. Interestingly, Staffordshire breed dogs had unique cytokine profiles, suggesting they may be more prone to this skin issue. Understanding these changes in immune proteins could help veterinarians diagnose and manage atopic dermatitis more effectively.
People also search for: dog skin allergy treatment · Staffordshire dog itching · atopic dermatitis in dogs symptoms
Abstract
BACKGROUND: Canine (Canis lupus familiaris) atopic dermatitis (AD) shares similar clinical signs to human AD. The abnormal immune response of AD is orchestrated by T lymphocytes, and may include variable involvement of cytokines, regulatory T (Treg) cells, eosinophils, mast cells and other immune components. Helper T (Th)2 cytokines often predominate initially, followed by Th1 cytokines in more chronic phases. HYPOTHESIS/OBJECTIVES: Pro-inflammatory and Treg cytokines have been shown to play a role in human AD, yet their importance is not clear in canine AD. Hence, this study aimed to measure the concentrations of cytokines/chemokines not traditionally associated with Th1/Th2 response. ANIMALS: Canine AD patients (n = 27), compared to control dogs (n = 11). METHODS AND MATERIALS: A total of 19 plasma cytokines were assayed using canine specific multiplex immuno-assays. RESULTS: The plasma concentrations of CXC Motif Chemokine Ligand 8 (CXCL8), interleukin (IL)-7 and IL-15 cytokines were elevated in canine AD patients, compared to control dogs. In addition, stem-cell factor (SCF) concentrations were reduced in the plasma of canine AD patients compared to control dogs. Distinct cytokine profiles were found in dogs belonging to the Staffordshire breeds, a group with increased risk of AD. In particular, granulocyte-macrophage colony-stimulating factor (GM-CSF) had significantly elevated concentrations. CONCLUSIONS AND CLINICAL RELEVANCE: Some of the plasma cytokine alterations in canine AD described here, particularly of IL-7, have not been reported previously. Monitoring these distinctive cytokine alterations could be useful for diagnosis and monitoring of canine AD in dogs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34817106/