Peer-reviewed veterinary case report
Altered β-adrenergic response in mice lacking myotonic dystrophy protein kinase.
- Journal:
- Muscle & nerve
- Year:
- 2012
- Authors:
- Llagostera, Esther et al.
- Affiliation:
- Institute of Biomedical Research August Pi i Sunyer · Spain
- Species:
- rodent
Abstract
The protein kinase product of the gene mutated in myotonic dystrophy 1 (DMPK) is reported to play a role in cardiac pathophysiology. To gain insight into the molecular mechanisms modulated by DMPK, we characterize the impact of DMPK ablation in the context of cardiac β-adrenergic function. Our data demonstrate that DMPK knockout mice present altered β-agonist-induced responses and suggest that this is due, at least in part, to a reduced density of β(1)-adrenergic receptors in cardiac plasma membranes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22190319/