Amelioration of convulsion-induced depression comorbidity by Rubus ellipticus whole plant extract in experimental models.

Abstract

Neuropsychiatric disorders are widespread and serious and have a detrimental effect on the patient's physical and mental health. The aim of the present study was to find the protective effect of Rubus ellipticus in epilepsy by maximal electroshock seizure, pentylenetetrazol, and related depressive behavior by Forced Swim Test and Tail Suspension Test. The animals were given ethanol extract of R. ellipticus (EERE) (100, 200, or 400 mg/kg) doses for 10 days. On every 5th day, seizure monitoring was performed (day 5 and day 10), followed by depressive behavior monitoring by evaluating immobility time. It was revealed that EERE treatment caused antidepressive-like behavior as a comorbid antiepileptogenic effect. This study will provide compelling evidence to support further clinical trials to grow this medicinal plant in the management of epileptogenic and associated debilitating behavioral comorbidities.