Peer-reviewed veterinary case report
Ameliorative and neuroprotective effect in MPTP model of Parkinson's disease by Zhen-Wu-Tang (ZWT), a traditional Chinese medicine.
- Journal:
- Journal of ethnopharmacology
- Year:
- 2010
- Authors:
- Li, Xiu-Min et al.
- Affiliation:
- Department of Pharmacology of Chinese Materia Medica · China
Abstract
AIM OF THE STUDY: Traditional Chinese medicine Zhen-Wu-Tang (ZWT) is a well-known PentaHerbs formula from "Treatise on Febrile Disease". This study is to elucidate its neuroprotective effect and mechanism of ameliorative effect of the syndrome of Parkinson's disease (PD). MATERIALS AND METHODS: The ameliorative effect of ZWT on symptom of PD through behavior tests including: swimming test, the tail suspension test and open-field test was investigated. The neuroprotective effect of dopaminergic neurons from the striatum and frontal cortex of brain was detected by high performance liquid chromatography with electrochemical detection (HPLC-ECD). RESULTS: This study proved that ZWT could ameliorate the typical symptom of PD and protect dopaminergic system. CONCLUSION: These results suggested that ZWT possessed protective and ameliorative properties of dopaminergic neurons.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20347948/