Aminoaciduric Canine Hypoaminoacidemic Hepatopathy Syndrome.

Abstract

Aminoaciduric canine hypoaminoacidemic hepatopathy syndrome is a multifaceted clinical condition that remains insufficiently understood, with its pathophysiology not yet fully delineated. Current evidence suggests a link between hypoaminoacidemia and the development of superficial necrolytic dermatitis and hepatocutaneous lesions (hypoaminoacidemia/hepatocutaneous-associated canine hepatopathy), although the underlying mechanisms driving these associations are not clearly defined. The presence of aminoaciduria, along with impaired amino acid transporter function in critical organs such as the skin, liver, and intestines, may play a significant role in the progression of this syndrome. Additionally, elevated glucagon levels may further contribute to the exacerbation of hypoaminoacidemia, worsening clinical signs.