Peer-reviewed veterinary case report
Amixicile Reduces Severity of Cryptosporidiosis but Does Not HaveActivity against Cryptosporidium.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2018
- Authors:
- Bartelt, Luther A et al.
- Affiliation:
- Department of Medicine · United States
Abstract
species cause significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition. Here, we show that amixicile, a highly selective water-soluble derivative of NTZ diminishesinfection severity in a malnourished mouse model despite a lack of direct anticryptosporidial activity. We suggest that amixicile, by tamping down anaerobes associated with intestinal inflammation, reverses weight loss and indirectly mitigates infection-associated pathology.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30297368/