Peer-reviewed veterinary case report
Great Dane developed gum overgrowth from amlodipine blood pressure
By Pariser, Marlene S & Berdoulay, Paul·Published in Journal of the American Animal Hospital Association·2011·Animal Allergy and Dermatology, United States·View original on PubMed →
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Original publication title: Amlodipine-induced gingival hyperplasia in a Great Dane.
- Species:
- dog
Plain-English summary
A 3-year-old female spayed Great Dane developed swollen gums after being treated for high blood pressure with a medication called amlodipine for 16 months. The only noticeable issue during the vet's exam was the severe gum swelling along with the high blood pressure. The vet switched her medication to hydralazine, and after nine months, her gum swelling nearly went away, and her blood pressure remained stable. This case highlights that while gum swelling can be a rare side effect of amlodipine, stopping the medication can lead to a full recovery.
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Abstract
A 3 yr old, 70 kg (154 lbs) female spayed Great Dane developed gingival hyperplasia after treatment of systemic hypertension with amlodipine 7.5 mg q 12 hr for 16 mo. Physical examination was unremarkable except for systemic hypertension and severe gingival hyperplasia. Amlodipine was replaced with hydralazine (0.72 mg/kg [0.32 mg/lb]). Nine months later, gingival hyperplasia was nearly resolved and hypertension was well controlled. Calcium channel blockers such as amlodipine are a rare cause of gingival hyperplasia in the canine patient. Recognition of this side effect is important because a full recovery can be achieved when the offending agent is removed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21852514/