Peer-reviewed veterinary case report
Amphotericin B for the treatment of localized subcutaneous phycomycosis in the horse.
- Journal:
- Journal of the American Veterinary Medical Association
- Year:
- 1977
- Authors:
- McMullan, W C et al.
- Species:
- horse
Plain-English summary
In this study, researchers looked at using a medication called Amphotericin B to treat a skin infection caused by a type of fungus in horses. Out of 10 horses treated, 8 showed good improvement. The treatment involved giving the medication through an IV, starting at a low dose and increasing as needed, and it was generally well tolerated by the horses. The best approach included removing the infected area surgically and then continuing with both IV and topical treatments of Amphotericin B, along with cleaning up any small dead tissue as needed. Overall, the treatment was effective for most of the horses.
Abstract
Amphotericin B was used systemically or locally, or both, in the treatment of localized subcutaneous phycomycosis in horses. In 8 of 10 cases, the results were satisfactory. Intravenous treatment was well tolerated at an average starting daily dosage of 0.38 mg/kg, increasing up to as high as 1.47 mg/kg. It was concluded that the ideal treatment regimen would include early surgical removal of the lesion followed by daily intravenous and topical administration of amphotericin B, with periodic extirpation of small necrotic tracts as necessary.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/863774/