Peer-reviewed veterinary case report
Amyloid-beta biomarkers in blood and spinal fluid of older dogs
By Stylianaki, Ioanna et al.·Published in Journal of veterinary internal medicine·2020·Department of Pathology·View original on PubMed →
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Original publication title: Amyloid-beta plasma and cerebrospinal fluid biomarkers in aged dogs with cognitive dysfunction syndrome.
- Species:
- dog
Plain-English summary
A group of older dogs with cognitive dysfunction syndrome (CDS) was studied to see if certain blood and cerebrospinal fluid (CSF) markers could help identify the condition. Researchers found that levels of a specific protein (Aβ42) in the CSF were higher in cognitively unimpaired dogs compared to those with mild cognitive impairment. This suggests that measuring these markers could help veterinarians better diagnose and understand cognitive issues in aging dogs. The findings indicate that these tests might be useful for identifying dogs at risk for cognitive decline, potentially leading to earlier intervention and treatment options.
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Abstract
BACKGROUND: Cognitive dysfunction syndrome (CDS) is a common progressive neurodegenerative disease that is poorly defined. Specific multitargeted protocols do not exist for setting the diagnosis and the prognosis of the syndrome. HYPOTHESIS/OBJECTIVES: To quantify Aβ42 and Aβ40 peptides in blood and cerebrospinal fluid (CSF) and to investigate their contribution to CCDS. ANIMALS: A total of 61 dogs from a hospital population. METHODS: Case-control study. Six young (YG: 0-4 years old), 8 middle-aged (4-8 years old), 17 cognitively unimpaired and aged (CU: 8-20 years old), and 30 cognitively impaired and aged (CI: 8-17 years). From the CI group, 10 dogs exhibited mild impairment (CI-MCI) and 20 exhibited severe impairment (CI-SCI). Cognitive status was assessed using a validated owner-based questionnaire. Direct and indirect Aβ markers were determined in plasma fractions (total-TP, free-FP, bound to plasma components-CP) and CSF using commercial ELISA assays (AΒtest, Araclon Biotech). RESULTS: TPAβ42/40 facilitated discrimination between CI-MCI and CU aged dogs with area under curve ≥ 0.79. CSFAβ42 levels were higher (P = .09) in CU (1.25 ± 0.28 ng/mL) than in MCI (1.04 ± 0.32 ng/mL) dogs. CSF Aβ42 levels were correlated with the CP fragment (CPAβ40: P = .02, CPAβ42: P = .02). CPAβ42 was higher in the CI-MCI (23.03 ± 11.79 pg/μL) group compared to the other aged dogs (CU: 10.42 ± 7.18 pg/μL, P = .02, SCI: 11.40 ± 12.98 pg/μL, P = .26). CONCLUSION AND CLINICAL IMPORTANCE: The Aβ should be determined in all of the 3 plasma fractions (TP, FP, CP). In the clinical approach, TPAβ42/40 could be used as an efficient preselection tool for the aged canine population targeting dogs with mild cognitive impairment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32557873/