Peer-reviewed veterinary case report
An activatable red emitting fluorescent probe for monitoring vicinal dithiol protein fluctuations in a stroke model.
- Journal:
- Chemical communications (Cambridge, England)
- Year:
- 2024
- Authors:
- Shen, Ruipeng et al.
- Affiliation:
- State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering · China
Abstract
Vicinal dithiol proteins (VDPs) facilitate cellular redox homeostasis, modulate protein synthesis and participate in post-translational modifications through the dynamic equilibrium of dithiol and disulfide bonds. Herein, an activatable red emitting fluorescent probe, VDP-red, is developed for detecting VDPs. With the aid of this probe, we have discovered for the first time a reduction in the levels of reduced VDPs in a stroke mouse model. This work provides a fresh viewpoint for understanding stroke mechanisms.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39499213/