Peer-reviewed veterinary case report
An efficient single prime protocol for the induction of antigen-induced airways inflammation.
- Journal:
- Journal of immunological methods
- Year:
- 2013
- Authors:
- Shaw, Odette M & Harper, Jacquie L
- Affiliation:
- Malaghan Institute of Medical Research
- Species:
- rodent
Abstract
There are a number of mouse models of allergic airway inflammation used to delineate various aspects of asthma. One of the hurdles with using mice is their natural resistance to developing a Th2 allergic response. This is often overcome by double priming with the allergen and an adjuvant. Here we report on an efficient 11day, single antigen/alum priming protocol that is sufficient to sensitise mice for the development of Th2-mediated inflammation in the lung following antigen challenge.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23831610/