Peer-reviewed veterinary case report
An experimental model for fatal malaria due to TNF-alpha-dependent hepatic damage.
- Journal:
- Parasitology
- Year:
- 2008
- Authors:
- Seixas, E et al.
- Affiliation:
- Instituto Gulbenkian de Ciê
- Species:
- rodent
Abstract
While BALB/c mice survive infection with blood stages of Plasmodium chabaudi chabaudi (AS), 70% of DBA/2 mice die by day 9-11 of infection, both strains controlling parasitaemia. We describe here that infection of DBA/2 mice results in extensive, multifocal hepatocyte death. Antibody neutralization of TNF-alpha prevents both liver damage and death.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18377697/