Peer-reviewed veterinary case report
An experimental model for induction of lung cancer in rats by Chlamydia pneumoniae.
- Journal:
- Asian Pacific journal of cancer prevention : APJCP
- Year:
- 2012
- Authors:
- Chu, De-Jie et al.
- Affiliation:
- Department of Pulmonary Medicine · China
- Species:
- rodent
Abstract
OBJECTIVE: To assess induction effects of Chlamydia pneumoniae (Cpn) on lung cancer in rats. METHODS: A lung cancer animal model was developed through repeated intratracheal injection of Cpn (TW-183) into the lungs of rats, with or without exposure to benzo(a)pyrene (Bp). Cpn antibodies (Cpn-IgA, -IgG, and -IgM) in serum were measured by microimmunofluorescence. Cpn-DNA or Cpn-Ag of rat lung cancer was detected through polymerase chain reaction or enzyme-linked immunosorbent assay. RESULTS: The prevalence of Cpn infection was 72.9% (35/48) in the Cpn group and 76.7% (33/43) in the Cpn plus benzo(a)pyrene (Bp) group, with incidences of lung carcinomas in the two groups of 14.6% (7/48) and 44.2% (19/43), respectively (P-values 0.001 and <0.001 compared with normal controls). CONCLUSIONS: A rat model of lung carcinoma induced by Cpn infection was successfully established in the laboratory for future studies on the treatment, prevention, and mechanisms of the disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22938465/