Peer-reviewed veterinary case report
An immune-mediated effect of the antibiotic cefiderocol on LPS-induced acute lung injury.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2026
- Authors:
- Hao, Min et al.
- Affiliation:
- Institute of Antibiotics · China
Abstract
UNLABELLED: This study examines the immune-modulatory effects of cefiderocol in a murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Cefiderocol pretreatment significantly reduced lung tissue damage, lowered pro-inflammatory cytokines, and decreased ferroptosis markers. Its protective effect was comparable to that of the ferroptosis inhibitor ferrostatin-1, while cefepime showed limited efficacy. These findings suggest that cefiderocol has an immuno-mediated role in LPS-induced ALI, potentially by modulating ferroptosis and inflammation, warranting further investigation for sepsis-related complications. IMPORTANCE: This study examines the immune-modulatory effects of cefiderocol in a murine model of LPS-induced acute lung injury (ALI). Cefiderocol pretreatment significantly reduced lung tissue damage, lowered pro-inflammatory cytokines, and decreased ferroptosis markers. Its protective effect was comparable to that of the ferroptosis inhibitor ferrostatin-1, while cefepime showed limited efficacy. These findings suggest that cefiderocol has an immuno-mediated role in LPS-induced ALI, potentially by modulating ferroptosis and inflammation, warranting further investigation for sepsis-related complications.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41705816/