Peer-reviewed veterinary case report
An immunocompetent rat model of infection with Cryptosporidium hominis and Cryptosporidium parvum.
- Journal:
- International journal for parasitology
- Year:
- 2020
- Authors:
- Dayao, Denise Ann et al.
- Affiliation:
- Department of Infectious Disease and Global Health · United States
- Species:
- rodent
Abstract
A major obstacle to developing vaccines against cryptosporidiosis, a serious diarrheal disease of children in developing countries, is the lack of rodent models essential to identify and screen protective immunogens. Rodent models commonly used for drug discovery are unsuitable for vaccine development because they either are purposefully immunodeficient or immunosuppressed. Here, we describe the development and optimization of an immunocompetent intratracheal (IT) rat model susceptible to infections with sporozoites of Cryptosporidium parvum and Cryptosporidium hominis - the primary causes of human cryptosporidiosis. A model suitable for screening of parasite immunogens is a prerequisite for immunogen screening and vaccine development.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31759945/