Peer-reviewed veterinary case report
Immune system causes of granulomatous scleritis in dogs
By Day, M J et al.·Published in Veterinary ophthalmology·2008·School of Clinical Veterinary Science, United Kingdom·View original on PubMed →
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Original publication title: An immunohistochemical investigation of canine idiopathic granulomatous scleritis.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog was brought in with eye problems, specifically inflammation and swelling around the eye, known as granulomatous scleritis. The vet found that the dog's condition was caused by an immune reaction rather than an infection. Treatment focused on managing the inflammation and addressing the immune response. Unfortunately, this dog later developed skin issues related to a systemic immune disorder, indicating that the underlying problem was more complex.
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Abstract
The clinical, histopathologic and immunohistochemical findings in three dogs with granulomatous scleritis are reported. The lesions of granulomatous scleritis were characterized by vasculitis, collagenolysis, granulomatous inflammation and perivascular lymphoplasmacytic aggregation. There was evidence of vascular immune complex deposition, and the inflammatory aggregates contained T lymphocytes, IgG plasma cells and macrophages expressing class II molecules of the major histocompatibility complex (MHC). There was no evidence for an infectious etiology in any case, and one of the dogs subsequently developed cutaneous vascular disease consistent with a systemic immune-mediated disorder. Canine granulomatous scleritis has an immunopathogenesis likely involving primary type IV hypersensitivity, with a probable underlying type III involvement.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18190346/