Peer-reviewed veterinary case report
An immunohistochemical study of an equine B-cell lymphoma.
- Journal:
- Journal of comparative pathology
- Year:
- 1994
- Authors:
- Asahina, M et al.
- Affiliation:
- Department of Veterinary Pathology · Japan
- Species:
- horse
Plain-English summary
Researchers studied the tissues of an 8-year-old male thoroughbred horse diagnosed with equine lymphoma, which is a type of cancer affecting the lymphatic system. They found abnormal growths in several areas, including the chest, lymph nodes in the abdomen, stomach lining, liver, and spleen. The cancerous cells were a mix of small and large types, and tests showed that these cells were from a specific type of immune cell called B-lymphocytes. This detailed examination helped confirm the nature of the lymphoma in this horse.
Abstract
The tissues of an 8-year-old thoroughbred castrated male horse with equine lymphoma were examined immunohistochemically. Neoplastic masses were observed in the mediastinum, mesenteric lymph nodes, gastric mucosa and serosa, liver capsule, and spleen capsule with associated lymph nodes. Histopathologically, the neoplastic cells were seen to consist predominantly of a mixture of well differentiated small and large types. Immunohistochemically, the small lymphoid cells were MHC class IIlow+ and PanT- and the large lymphoid cells were MHC class IIhigh+ and PanT-. These findings revealed that the neoplastic cells were of B-lymphocyte lineage.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/7884061/