Peer-reviewed veterinary case report
Higher prostaglandin and platelet-activating factor in urine of dogs
By Yamazaki, Arisa et al.·Published in The Journal of veterinary medical science·2025·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: An increase in the urinary levels of prostaglandin Dand platelet-activating factor metabolites in dogs with mast cell tumor.
- Species:
- dog
Plain-English summary
A dog with a mast cell tumor (MCT) may show symptoms like swelling or lumps on the skin, which can sometimes lead to severe allergic reactions. Researchers found that dogs with MCT had higher levels of certain substances in their urine that could help diagnose this condition without invasive procedures. Specifically, they identified several lipid metabolites that were significantly elevated in dogs with MCT compared to healthy dogs. This discovery could lead to new, safer ways to diagnose mast cell tumors in dogs.
People also search for: dog mast cell tumor symptoms · non-invasive mast cell tumor diagnosis · elevated urine metabolites in dogs
Abstract
The diagnosis of canine mast cell tumor (MCT) via cytology carries the risk of triggering life-threatening anaphylactic reactions due to massive histamine release. Since mast cells release various lipid mediators, which are excreted in urine, we aimed to explore urinary lipid metabolites as potential non-invasive diagnostic markers for MCT. Liquid chromatography-mass spectrometry-based analysis detected 32 types of lipid metabolites in the urine of MCT dogs. Among these, urinary levels of 15-deoxy-Δ-12,14-PGJ, lyso-PAF, 9,10-DiHOME, and 12,13-DiHOME were significantly elevated in MCT dogs compared to healthy dogs. These urinary lipid metabolites can serve as novel non-invasive biomarkers for canine MCT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39993735/