Peer-reviewed veterinary case report
An increase in the urinary levels of prostaglandin Dand platelet-activating factor metabolites in dogs with mast cell tumor.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2025
- Authors:
- Yamazaki, Arisa et al.
- Affiliation:
- Graduate School of Agricultural and Life Sciences · Japan
- Species:
- dog
Abstract
The diagnosis of canine mast cell tumor (MCT) via cytology carries the risk of triggering life-threatening anaphylactic reactions due to massive histamine release. Since mast cells release various lipid mediators, which are excreted in urine, we aimed to explore urinary lipid metabolites as potential non-invasive diagnostic markers for MCT. Liquid chromatography-mass spectrometry-based analysis detected 32 types of lipid metabolites in the urine of MCT dogs. Among these, urinary levels of 15-deoxy-Δ-12,14-PGJ, lyso-PAF, 9,10-DiHOME, and 12,13-DiHOME were significantly elevated in MCT dogs compared to healthy dogs. These urinary lipid metabolites can serve as novel non-invasive biomarkers for canine MCT.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39993735/