An increasing electromechanical window is a predictive marker of ventricular fibrillation in anesthetized rabbit with ischemic heart.

Abstract

The QTc interval is widely used in Safety Pharmacological studies to predict arrhythmia risk, and the electromechanical window (EMW) and short-term variability of QT intervals (STV) have been studied as new biomarkers for drug-induced Torsades de Pointes (TdP). However, the use of EMW and STVto predict ventricular fibrillation (VF) has not been elucidated. This study aimed to evaluate EMW and STVto predict VF in anesthetized rabbit model of VF. VF was induced by ligation of the left anterior descending and a descending branch of the left circumflex coronary arteries in a sample population of rabbits (n=18). VF was developed 55.6% (10/18). In rabbit with VF, the EMW was significantly higher than in rabbits without VF (96.3 &#xb1; 15.6 ms and 49.5 &#xb1; 5.6 ms, respectively, P<0.05). STVhad significantly increased before the onset of VF in rabbits that experienced VF, but not in rabbits that did not experience VF (11.7 &#xb1; 1.8 ms and 3.7 &#xb1; 0.4 ms, respectively, P<0.05). The EMW and STVhad better predictive power for VF with higher sensitivity and specificity than the QTc measure. The result suggested that the increasing of EMW, as well as the elevation of STV, can potentially be used as biomarkers for predicting of VF.