Peer-reviewed veterinary case report
IgE allergy to house dust mites in atopic dogs worldwide
By Favrot, Claude et al.·Published in Veterinary dermatology·2022·Clinic for Small Animal Internal Medicine·View original on PubMed →
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Original publication title: An international seroprevalence survey of the IgE sensitisation to the Dermatophagoides farinae house dust mite and two of its major allergens (Der f 2, Zen 1) in atopic dogs.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy) were tested for sensitivity to house dust mites, specifically the allergens Der f 2 and Zen 1. The study found that a high percentage of these dogs across various countries had IgE antibodies to the dust mite allergens, with rates ranging from 74% to 100% depending on the location. This suggests that many dogs with skin allergies are likely reacting to these common allergens. Understanding these sensitivities can help veterinarians create better treatment plans for managing atopic dermatitis in dogs.
People also search for: dog skin allergy treatment · why is my dog itching · house dust mite allergy in dogs
Abstract
BACKGROUND: Dogs with atopic dermatitis are often immunoglobulin (Ig)E-sensitised to Dermatophagoides farinae (Df) house dust mites, yet limited data exist on the sensitisation rates to the individual Df allergens, Der f 2 and Zen 1. OBJECTIVES: To determine the IgE sensitisation rates to Df, Der f 2 and Zen 1 in atopic dogs from geographically diverse countries. ANIMALS: Serum was collected from 32 laboratory dogs in Japan, and 837 atopic dogs from 11 countries from five continents: Asia (Japan, Thailand, Taiwan), Europe (Italy, Latvia, the Netherlands, UK), North America (USA), South America (Argentina, Brazil) and Africa (South Africa). METHODS AND MATERIALS: We determined Df-, Der f 2- and Zen 1-specific IgE levels by ELISA. Correlations between the IgE values for these three allergens were calculated. RESULTS: The IgE seropositivity rates for Df varied between 74% (Argentina) and 100% (the Netherlands, Thailand, South Africa), those for Der f 2 between 12% (Argentina) and 88% (South Africa), and for Zen 1 between 70% (Argentina) and 100% (the Netherlands). Apart from the especially low seropositivity rate for Der f 2-specific IgE in Argentina, the percentage of IgE sensitisation varied little between countries. There was significant correlation between the IgE levels to these three allergens which was highest between Df and Zen 1, and lowest between Zen 1 and Der f 2. CONCLUSIONS AND CLINICAL RELEVANCE: The IgE sensitisation to Df is geographically widespread. Der f 2 and Zen 1 are major allergens for dogs in almost all countries where this was evaluated.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34414620/