Peer-reviewed veterinary case report
Testing antiviral drugs GS-441524, remdesivir, and molnupiravir
By Cook, Sarah et al.·Published in Viruses·2022·Department of Pathology, United States·View original on PubMed →
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Original publication title: An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats.
- Species:
- cat
Plain-English summary
A group of cats with feline infectious peritonitis (FIP), a serious and often fatal disease, was studied to find effective antiviral treatments. Researchers tested several antiviral medications, including remdesivir and GS-441524, to see how well they worked against the virus that causes FIP. They found that these medications could be given orally and were effective at the right doses, maintaining high enough levels in the blood to fight the virus for at least 24 hours. This research suggests that these treatments could be promising options for managing FIP in cats.
People also search for: cat FIP treatment · remdesivir for cats · GS-441524 dosage for feline infectious peritonitis
Abstract
Feline infectious peritonitis (FIP) is a fatal disease of cats that currently lacks licensed and affordable vaccines or antiviral therapeutics. The disease has a spectrum of clinical presentations including an effusive ("wet") form and non-effusive ("dry") form, both of which may be complicated by neurologic or ocular involvement. The feline coronavirus (FCoV) biotype, termed feline infectious peritonitis virus (FIPV), is the etiologic agent of FIP. The objective of this study was to determine and compare the in vitro antiviral efficacies of the viral protease inhibitors GC376 and nirmatrelvir and the nucleoside analogs remdesivir (RDV), GS-441524, molnupiravir (MPV; EIDD-2801), and β-D-N-hydroxycytidine (NHC; EIDD-1931). These antiviral agents were functionally evaluated using an optimized in vitro bioassay system. Antivirals were assessed as monotherapies against FIPV serotypes I and II and as combined anticoronaviral therapies (CACT) against FIPV serotype II, which provided evidence for synergy for selected combinations. We also determined the pharmacokinetic properties of MPV, GS-441524, and RDV after oral administration to cats in vivo as well as after intravenous administration of RDV. We established that orally administered MPV at 10 mg/kg, GS-441524 and RDV at 25 mg/kg, and intravenously administered RDV at 7 mg/kg achieves plasma levels greater than the established corresponding ECvalues, which are sustained over 24 h for GS-441514 and RDV.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36366527/