Peer-reviewed veterinary case report
An Outbreak of Fatal Bordetella bronchiseptica Bronchopneumonia in Puppies.
- Journal:
- Journal of comparative pathology
- Year:
- 2019
- Authors:
- Chambers, J K et al.
- Affiliation:
- Graduate School of Agricultural and Life Sciences · Japan
- Species:
- dog
Plain-English summary
A group of twenty-two newborn puppies at a breeding facility became very sick and died because they did not receive the important first milk called colostrum. Four of these puppies were examined after they passed away, and the tests showed that their lungs were firm and had a dark red color, which is a sign of a severe lung infection called bronchopneumonia. The tests also found a lot of certain bacteria, Bordetella bronchiseptica, which can cause respiratory illness, attached to the tiny hairs in their lungs. These findings confirmed that the puppies had a serious and fatal lung infection caused by this bacteria.
Abstract
Twenty-two newborn puppies that did not receive colostrum exhibited acute respiratory signs and died at a breeding facility. Pathological examinations were performed on four of the puppies. At necropsy examination, the lungs were firm and mottled dark red, consistent with acute bronchopneumonia. Histopathologically, there was marked infiltration of neutrophils and macrophages into the bronchi and alveoli, and gram-negative coccobacilli were attached diffusely to the cilia of bronchial mucosa. Immunohistochemistry for Bordetella bronchiseptica antigen revealed positive labelling of the bacterial agents. On electron microscopy, a large number of coccobacilli were observed attaching to the cilia of bronchial epithelial cells. Real-time polymerase chain reaction amplified a B. bronchiseptica gene from the affected lung tissue. Based on these findings, the four puppies were diagnosed with fatal B. bronchiseptica bronchopneumonia.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30898296/