Peer-reviewed veterinary case report
Fatal Bordetella bronchiseptica pneumonia outbreak in newborn puppies
By Chambers, J K et al.·Published in Journal of comparative pathology·2019·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: An Outbreak of Fatal Bordetella bronchiseptica Bronchopneumonia in Puppies.
- Species:
- dog
Plain-English summary
Twenty-two newborn puppies at a breeding facility developed severe breathing problems and sadly died because they did not receive colostrum (the first milk rich in antibodies). Four of these puppies were examined after death, revealing that their lungs were severely inflamed and infected with Bordetella bronchiseptica, a bacteria that can cause pneumonia. This infection was confirmed through various tests, including looking at the lung tissue under a microscope. Unfortunately, the puppies did not survive due to the severity of the illness.
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Abstract
Twenty-two newborn puppies that did not receive colostrum exhibited acute respiratory signs and died at a breeding facility. Pathological examinations were performed on four of the puppies. At necropsy examination, the lungs were firm and mottled dark red, consistent with acute bronchopneumonia. Histopathologically, there was marked infiltration of neutrophils and macrophages into the bronchi and alveoli, and gram-negative coccobacilli were attached diffusely to the cilia of bronchial mucosa. Immunohistochemistry for Bordetella bronchiseptica antigen revealed positive labelling of the bacterial agents. On electron microscopy, a large number of coccobacilli were observed attaching to the cilia of bronchial epithelial cells. Real-time polymerase chain reaction amplified a B. bronchiseptica gene from the affected lung tissue. Based on these findings, the four puppies were diagnosed with fatal B. bronchiseptica bronchopneumonia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30898296/