Peer-reviewed veterinary case report
An overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines.
- Journal:
- Journal of immunology research
- Year:
- 2014
- Authors:
- Dong, Bo et al.
- Affiliation:
- Department of Preventive Veterinary Medicine · China
Abstract
Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controlling viral infections in animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24995348/