Peer-reviewed veterinary case report
An overview of various mammalian models to study chronic copper intoxication associated Alzheimer's disease like pathology.
- Journal:
- Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
- Year:
- 2015
- Authors:
- Pal, Amit & Prasad, Rajendra
- Affiliation:
- Department of Biochemistry · India
Abstract
Chronic copper toxicity has been long known to cause hepatotoxicity and liver cirrhosis as observed in Wilson's disease; however, substantial evidence accrued over the time have shown considerable increase in animal studies demonstrating Alzheimer's disease like pathology due to chronic copper-intoxication under certain conditions. This review integrates the contemporary mammalian studies in which the effect of chronic copper intoxication was assessed on the central nervous system and cognition of animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25307560/