Peer-reviewed veterinary case report
Pain relief after spay surgery in cats with vedaprofen and tramadol
By Brondani, Juliana Tabarelli et al.·Published in Journal of feline medicine and surgery·2009·Department of Veterinary Surgery and Anaesthesiology, Brazil·View original on PubMed →
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Original publication title: Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy.
- Species:
- cat
Plain-English summary
A group of 40 adult female cats undergoing spay surgery (ovariohysterectomy) were given either a combination of two pain medications, vedaprofen and tramadol, or a placebo to see which worked better for pain relief. The cats that received both medications experienced significantly less pain and did not require additional pain relief after surgery. They also showed no signs of increased sensitivity to pain, which can happen after surgery. This combination treatment proved to be more effective than using either medication alone, providing relief for up to three days post-surgery.
People also search for: cat spay surgery pain relief · vedaprofen tramadol for cats · postoperative pain management in cats
Abstract
The analgesic efficacy of tramadol and/or vedaprofen was evaluated in cats submitted for elective ovariohysterectomy, using a randomised double blind placebo controlled design. Forty adult female cats (3.0+/-0.32kg; 1.8+/-0.7 years) were distributed into four groups. Vedaprofen PO (0.5mg/kg), tramadol SC (2mg/kg), both, or placebo was administered 1h before surgery and every 24 and 8h, respectively, for 72h after surgery. Pain score evaluated by interactive visual analogue and composite pain score and hyperalgesia by the von Frey filament test were recorded at 1, 2, 4, 6, 8, 12, 24, 28, 32, 48, 52, 56, 72, 96h and on the 7th day after surgery. Animals treated with combined vedaprofen and tramadol treatment did not need rescue analgesia, did not develop hyperalgesia, and their serum cortisol concentrations and pain scores were lower than placebo until 24 and 72h after surgery, respectively. Combined vedaprofen and tramadol treatment provided more effective postoperative analgesia and prevented hyperalgesia than when used on their own. Multimodal technique is a superior method of treating pain after feline ovariohysterectomy. This work also provides evidence for the benefits of analgesia for up to 3 days following ovariohysterectomy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19233698/