Peer-reviewed veterinary case report
Gene deletion linked to eye disease in wire-haired Dachshunds only
By Palánová, Anna et al.·Published in Veterinary ophthalmology·2014·Institute of Animal Physiology and Genetics·View original on PubMed →
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Original publication title: Analysis of a deletion in the nephronophthisis 4 gene in different dog breeds.
- Species:
- dog
Plain-English summary
A study found that a genetic mutation linked to cone-rod dystrophy, a progressive eye disease, is present in both standard and miniature wire-haired Dachshunds. This mutation affects their vision and can lead to serious eye problems over time. The research showed that this specific genetic deletion in the nephronophthisis 4 gene was not found in other types of Dachshunds or in different breeds. If you have a wire-haired Dachshund, it's important to monitor their eye health and discuss any concerns with your veterinarian.
People also search for: Dachshund eye problems · cone-rod dystrophy in dogs · Dachshund genetic disorders
Abstract
Cone-rod dystrophy is a progressive inherited retinal degenerative disorder that occurs in humans and dogs. The deletion in the nephronophthisis 4 (NPHP4) gene was established as a causative mutation in standard wire-haired Dachshunds. We analyzed all varieties of Dachshunds from the Czech Republic and five other dog breeds and found that the deletion in the NPHP4 (in heterozygous state) is present not only in standard-, but also in miniature wire-haired Dachshunds, but not in other varieties of Dachshunds or in other breeds.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23998563/