Peer-reviewed veterinary case report
Cartilage protein and enzyme levels in dachshunds with disc herniation
By Nagano, Shinichi et al.·Published in Research in veterinary science·2012·Department of Veterinary Clinical Science, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Analysis of cartilage oligomeric matrix protein and matrix metalloproteinase-9 in cerebrospinal fluid of miniature dachshund with intervertebral disc herniation.
- Species:
- dog
Plain-English summary
A group of miniature dachshunds with intervertebral disc herniation (a condition where the discs in the spine bulge and press on nerves) underwent surgery called hemilaminectomy. Out of 23 dogs treated, 20 made a full recovery, while 3 dogs that showed no deep pain sensation had a poor outcome. Researchers found that the levels of certain proteins in the dogs' cerebrospinal fluid were higher in those with the condition compared to healthy dogs. The study suggested that specific protein levels might help predict recovery chances, especially in more severe cases.
People also search for: miniature dachshund back surgery recovery · intervertebral disc herniation treatment · dog spinal surgery prognosis
Abstract
We evaluated whether the cerebrospinal fluid (CSF) concentration of cartilage oligomeric matrix protein (COMP) is related to disease severity, prognosis and matrix metalloproteinase (MMP)-9 activity of the CSF in miniature dachshund with intervertebral disc herniation. Samples were obtained from 23 patients and 6 normal dogs, and all patients received hemilaminectomy. Twenty dogs recovered successfully and 3 of 11 dogs without deep nociception had MMP-9 activity in the CSF and an unsuccessful outcome. The COMP levels from patients were significantly higher than those from normal dogs. MMP-9 activity and neurological severity were not related to the COMP levels. However, the COMP levels from 3 unsuccessful cases that had MMP-9 activity were significantly lower than those from all recovered cases and/or successful cases without deep nociception. Concerning severe cases, increased proteolytic activity might affect the COMP concentration and prognosis due to MMP-9 associated deleterious effects.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22440362/