Peer-reviewed veterinary case report
Genes linked to anal furunculosis in German shepherd dogs
By House, A K et al.·Published in Tissue antigens·2009·Department of Veterinary Clinical Science, United Kingdom·View original on PubMed →
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Original publication title: Analysis of NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 genes in anal furunculosis of German shepherd dogs.
- Species:
- dog
Plain-English summary
A group of German shepherd dogs with anal furunculosis (AF) were studied to understand why this condition, which causes painful inflammation and ulceration around the rear end, is more common in this breed. Researchers looked at specific genes related to the immune system to see if any genetic factors made these dogs more susceptible to AF. They found that certain genetic variations were less common in German shepherds compared to other breeds, suggesting that selective breeding might have affected their immune responses. However, they did not find strong links between specific gene changes and the development of AF.
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Abstract
Anal furunculosis (AF) primarily affects German shepherd dogs (GSD) and is characterised by inflammation and ulceration of the perianal tissues with development of cutaneous sinuses or rectocutaneous fistulae. Investigation of pattern recognition receptor (PRR) function has suggested that defective responses might occur in AF-affected GSD. The aim of the current study was to investigate whether canine PRR genes are involved in determining susceptibility to AF in this breed. Chromosomal location and coding sequences for NOD1, NOD2, TLR1, TLR2, TLR4, TLR5, TLR6 and TLR9 were determined and microsatellite markers identified for each gene. Microsatellite genotyping of 100 control GSD and 47 AF-affected GSD showed restricted allelic variation for AHT H91 (associated with TLR5) and REN216 NO5 (associated with both TLR1 and TLR6) compared with non-GSD dogs. Genotyping of single nucleotide polymorphisms identified in canine TLR1, TLR5, TLR6 and NOD2 genes failed to show any significant associations between PRR polymorphisms and AF. The highly restricted PRR genotypes seen in GSD are likely to have resulted from selective breeding and might influence innate immune responses in this breed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19254256/