Peer-reviewed veterinary case report
Analysis of T-Cells in Inflamed Nonlymphoid Tissues.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2021
- Authors:
- Bauer, Laura & Hutloff, Andreas
- Affiliation:
- A Leibniz Institute · Germany
Abstract
Under chronic inflammatory conditions, T and B cells are frequently found in nonlymphoid tissues. We recently identified a follicular helper-like T cell population in inflamed lung tissue, which drives the local differentiation of antigen-specific B cells into germinal center-like cells and plasma blasts. Here, we describe a lung inflammation mouse model, which is ideally suited to analyze antigen-specific T and B cells in secondary lymphoid organs and inflamed nonlymphoid tissue in parallel.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33928545/