Peer-reviewed veterinary case report
Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection.
- Journal:
- Veterinary research
- Year:
- 2020
- Authors:
- Yang, Jing et al.
- Affiliation:
- Institute of Veterinary Medicine · China
- Species:
- bird
Abstract
MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33069243/