Peer-reviewed veterinary case report
Anaphylactoid reaction and lung effects from Optison in two dogs
By Yamaya, Yoshiki et al.·Published in The Journal of veterinary medical science·2004·Department of Medicine, United States·View original on PubMed →
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Original publication title: Anaphylactoid response to Optison(R) and its effects on pulmonary function in two dogs.
- Species:
- dog
Plain-English summary
Two dogs experienced severe allergic reactions after receiving a cardiac imaging agent called Optison during anesthesia. These reactions were linked to a component derived from human blood, but they resolved on their own. The dogs were kept stable with mechanical ventilation and other supportive measures during the episodes. To prevent similar reactions in the future, it’s recommended that veterinarians check blood pressure responses before using Optison and be prepared with emergency airway access and medications.
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Abstract
Two of 26 anesthetized dogs given the cardiac echo-enhancing agent Optison showed anaphylactoid responses (AR) related to the human albumin component of this agent. The episodes of AR were self-limited, and could be reproduced by human albumin injection alone. Gas exchange was maintained by mechanical ventilation and 5 cm H(2)O PEEP, and dispersion of ventilation remained normal during AR despite severe hypotension. We suggest that: (1) pre-screening by measuring blood pressure response to intravenous injection of small doses of Optison, and (2) availability of access to the airway in addition to emergency agents may be prudent preventive measures when Optison is used in animals to enhance echocardiographic imaging.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15585961/