Peer-reviewed veterinary case report
Dog vomited and had low blood pressure after alphaxalone injection
By Haworth, M et al.·Published in Australian veterinary journal·2019·Veterinary Teaching Hospital, Australia·View original on PubMed →
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Original publication title: Anaphylaxis associated with intravenous administration of alphaxalone in a dog.
- Species:
- dog
Plain-English summary
A spayed female cattle dog experienced vomiting and diarrhea after receiving an intravenous anesthetic called Alfaxan during a routine procedure for her limping front leg. This reaction was identified as anaphylaxis, a severe allergic response, which also caused a drop in blood pressure. The veterinary team quickly treated her by giving fluids, and fortunately, she did not need adrenaline. Within six hours, she had fully recovered and was able to undergo another procedure three days later without any issues, this time using a different anesthetic called propofol.
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Abstract
CASE REPORT: We describe the clinical signs and management of a case of anaphylaxis in a dog after intravenous administration of alphaxalone (Alfaxan®, Jurox, NSW, Aust), which has not been previously published. A female spayed cattle dog undergoing routine imaging for forelimb lameness was induced with Alfaxan after receiving sedation with acepromazine and methadone 70 min prior. Immediately after intravenous administration of Alfaxan, the dog exhibited vomiting and diarrhoea associated with acute hypotension. Gallbladder wall oedema was visualised consistent with anaphylaxis. The dog responded to rapid volume expansion. Adrenaline was not required. The dog made a full recovery within 6 h of the reaction and was re-anaesthetised 3 days later without incident, using propofol as the induction agent. CONCLUSION: To our knowledge, this is the first published case of anaphylaxis associated with intravenous Alfaxan in the dog. The APVMA reporting of reactions in small animals from 2003 to 2013 of Alfaxan is consistent with this case report's finding involving the respiratory, circulatory and gastrointestinal systems.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31136692/