Peer-reviewed veterinary case report
Dog with rare skin tumors from aggressive myeloma treated with chemo
By Fukumoto, Shinya et al.·Published in The Journal of veterinary medical science·2012·Department of Small Animal Clinical Sciences, Japan·View original on PubMed →
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Original publication title: Anaplastic atypical myeloma with extensive cutaneous involvement in a dog.
- Species:
- dog
Plain-English summary
A 7-year-old male mixed breed dog was brought to the vet because he was not eating, limping, and had several skin lesions. Tests revealed he had multiple myeloma, a type of cancer that affects plasma cells in the bone marrow and can cause skin problems. The dog was treated with a combination of medications, including melphalan and prednisone, and managed to live for 175 days after diagnosis. This case highlights a rare form of multiple myeloma that also affected the dog's skin.
People also search for: dog skin lesions · dog not eating and limping · multiple myeloma treatment in dogs
Abstract
A 7-year-old, male, mixed breed dog was referred to the Veterinary Teaching Hospital at Kitasato University because of anorexia, lameness and multiple cutaneous lesions. Observation of bone marrow plasmacytosis, osteolytic bone lesions, serum myeloma protein and cutaneous infiltration of myeloma cells led us to a diagnosis of multiple myeloma (MM) with cutaneous involvement. Polymerase chain reaction and sequence analysis for the rearranged genes of immunoglobulin and T-cell receptor demonstrated that the neoplastic cells found in skin lesions or bone marrow are of B-lymphocyte lineage and share a common original precursor cell. The dog was treated with UW-Madison protocol or melphalan/prednisone protocol and survived 175 days. This is rare case of anaplastic MM with cutaneous involvement in dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21873808/