and canine periodontal disease: Current understanding and future directions.

Abstract

has emerged as a notable pathogen in canine periodontal disease, akin toin human periodontitis. This review examines the initial isolation, phylogenetic analysis, habitat, host range, relationships with host health status and age, and key pathogenic determinants, including fimbriae, proteases, citrullinating enzyme, and lipopolysaccharide. Control strategies discussed include polyphosphate to disrupt haeme/iron utilization, clindamycin with interferon alpha to reduce bacterial load and enhance the immune response, and a protease inhibitor. Further research is needed to understand strain-level diversity of virulence factors and interactions betweenand other oral bacteria, particularly, a common pathogen in both dogs and humans. The potential for interspecies transmission between dogs and humans warrants further research into these interactions. Extensivestudies across various breeds are crucial to validate the effectiveness of proposed treatment strategies. This review emphasizes's role in periodontal health and disease, setting the stage for future research and improved management of canine periodontal disease.