andantiviral activity of monolaurin against.

Abstract

INTRODUCTION: Surveillance of the(SVV) shows a disproportionately higher incidence on Chinese pig farms. Currently, there are no vaccines or drugs to treat SVV infection effectively and effective treatment options are urgently needed. METHODS: In this study, we evaluated the antiviral activity of the following medium-chain fatty acids (MCFAs) or triglycerides (MCTs) against SVV: caprylic acid, caprylic monoglyceride, capric monoglyceride, and monolaurin. RESULTS: experiments showed that monolaurin inhibited viral replication by up to 80%, whilestudies showed that monolaurin reduced clinical manifestations, viral load, and organ damage in SVV-infected piglets. Monolaurin significantly reduced the release of inflammatory cytokines and promoted the release of interferon-γ, which enhanced the viral clearance activity of this type of MCFA. DISCUSSION: Therefore, monolaurin is a potentially effective candidate for the treatment of SVV infection in pigs.