Peer-reviewed veterinary case report
Angiogenesis inhibition using an oncolytic herpes simplex virus expressing endostatin in a murine lung cancer model.
- Journal:
- Cancer investigation
- Year:
- 2012
- Authors:
- Goodwin, Jonathan M et al.
- Affiliation:
- Massachusetts General Hospital Cancer Center · United States
Abstract
Herpes-mediated viral oncolysis alone is not sufficient to completely eradicate tumors. In this study we used a replication conditional, endostatin-expressing herpes simplex virus-1 mutant (HSV-Endo) in a murine lung cancer model. We hypothesized that the anti-angiogenic action of endostatin would improve upon the oncolytic effect of HSV-1. HSV-Endo was evaluated in a pulmonary metastases and orthotopic flank model, where there was significantly less tumor burden and reduced microvessel density compared to a control virus. Endostatin expression appears to improve the anti-tumor effect of HSV-1 in a lung cancer model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22360364/