Peer-reviewed veterinary case report
Anidulafungin treatment of candidal central nervous system infection in a murine model.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2009
- Authors:
- Kang, Cheol-In et al.
- Affiliation:
- Sungkyunkwan University School of Medicine · South Korea
Abstract
We established a murine model of Candida albicans central nervous system (CNS) infection and evaluated the efficacy of anidulafungin. Ten milligrams/kg/day anidulafungin, amphotericin B, or voriconazole significantly reduced mortality and fungal burden in brain tissue, although amphotericin B and 10 mg/kg/day anidulafungin reduced fungal burden in brain tissue to a greater extent than did voriconazole. This suggests a potential role for anidulafungin in the treatment of candidal CNS infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19506064/