Peer-reviewed veterinary case report
Animal models for filovirus infections.
- Journal:
- Zoological research
- Year:
- 2018
- Authors:
- Siragam, Vinayakumar et al.
- Affiliation:
- Special Pathogens Program · Canada
- Species:
- rodent
Abstract
The family, which includes the generaand, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29511141/