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Peer-reviewed veterinary case report

Animal models of dyssynchrony.

Journal:
Journal of cardiovascular translational research
Year:
2012
Authors:
Strik, Marc et al.
Affiliation:
Department of Physiology · Netherlands

Abstract

Cardiac resynchronization therapy (CRT) is an important therapy for patients with heart failure and conduction pathology, but the benefits are heterogeneous between patients and approximately a third of patients do not show signs of clinical or echocardiographic response. This calls for a better understanding of the underlying conduction disease and resynchronization. In this review, we discuss to what extent established and novel animal models can help to better understand the pathophysiology of dyssynchrony and the benefits of CRT.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/22130900/