Peer-reviewed veterinary case report
Understanding animal models for stroke research and care
By Graham, Sharon M et al.·Published in Comparative medicine·2004·Department of Anesthesiology and Peri-Operative Medicine, United States·View original on PubMed →
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Original publication title: Animal models of ischemic stroke: balancing experimental aims and animal care.
Plain-English summary
This research discusses the use of animal models to study ischemic stroke, which is a type of stroke caused by a blockage of blood flow to the brain. It highlights the challenges of balancing the goals of the research with the care of the animals involved. The paper reviews what is currently known about strokes in humans, outlines important questions that still need answers, and examines different animal models used for this type of research, noting their pros and cons. It emphasizes the importance of good communication among researchers, veterinarians, and animal care staff to ensure that both research needs and animal welfare are respected. Overall, the study aims to improve how we conduct research while caring for the animals involved.
Abstract
Animal models of ischemic stroke are examples of an induced model that can present challenges from the perspectives of protocol review and animal management. The review presented here will include a brief summary of the current state of knowledge about clinical stroke; a general synopsis of important unanswered research questions that justify use of animal stroke models; an overview of various animal models of ischemic stroke, including strengths and limitations; and a discussion of animal care issues relative to ischemic stroke models. Good communication and interactive education among primary investigators, laboratory animal veterinarians and caretakers, and institutional animal care and use committee members are critical in achieving a balance between research objectives and animal care issues when using animal stroke models.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15575362/