Peer-reviewed veterinary case report
Animal models of multiple system atrophy.
- Journal:
- Clinical autonomic research : official journal of the Clinical Autonomic Research Society
- Year:
- 2015
- Authors:
- Stefanova, Nadia & Wenning, Gregor K
- Affiliation:
- Department of Neurology
Abstract
Since their introduction in 1996, animal models of multiple system atrophy (MSA) have generated important insights into pathogenesis and interventional therapies. Toxin and genetic approaches have been used alone or in combination to replicate progressive motor and non-motor symptoms reflecting human neuropathology. Here, we review these developments and discuss the advantages and limitations of the MSA animal models, as well as their application in preclinical target validation.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25585910/