Peer-reviewed veterinary case report
Animal models of Vogt-Koyanagi-Harada disease (sympathetic ophthalmia).
- Journal:
- Ophthalmic research
- Year:
- 2008
- Authors:
- Yamaki, Kunihiko & Ohono, Shigeaki
- Affiliation:
- Department of Ophthalmology · Japan
Abstract
BACKGROUND/AIMS: We aimed to establish the animal model of Vogt-Koyanagi-Harada disease (VKH). METHODS: Rats, Akita dogs and monkeys were immunized with the peptides derived from tyrosinase-related protein 1. Each experimental animal was examined clinically and histologically. RESULTS AND CONCLUSION: The rats developed ocular and extraocular inflammation homologous to human VKH by immunization of tyrosinase-related protein 1. The Akita dogs also developed the autoimmune disease almost similar to the spontaneously emerging dog VKH equivalent to human VKH. The monkeys developed similar clinical findings as human VKH. These models may serve as human VKH models.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18421226/