Peer-reviewed veterinary case report
Antagonism of quercetin against tremor induced by unilateral striatal lesion of 6-OHDA in rats.
- Journal:
- Journal of Asian natural products research
- Year:
- 2016
- Authors:
- Mu, Xin et al.
- Affiliation:
- a Institute of Materia Medica · China
- Species:
- rodent
Abstract
Quercetin, a flavonoid present in many plants, is reported to be effective in models of neurodegenerative diseases. The aim of the present study was to evaluate the anti-tremor effects of quercetin in 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease. In rats, quercetin had no effect on apomorphine-induced rotations, but it could significantly attenuate muscle tremor of 6-OHDA lesioned rats. Interestingly, quercetin could decrease the burst frequency in a dose- and time-dependent manner. These results suggest that quercetin may have a protective effect on models to mimic muscle tremors of Parkinson's disease. This effect of quercetin may be associated with serotonergic system, but further study is needed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26217978/