Peer-reviewed veterinary case report
How atipamezole helps cats recover
By Ueoka, Naotami & Hikasa, Yoshiaki·Published in Journal of feline medicine and surgery·2008·Ueoka Animal Hospital, Japan·View original on PubMed →
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Original publication title: Antagonistic effects of atipamezole, flumazenil and 4-aminopyridine against anaesthesia with medetomidine, midazolam and ketamine combination in cats.
- Species:
- cat
Plain-English summary
A group of cats that were put under anesthesia using a combination of medications (medetomidine, midazolam, and ketamine) were tested to see how well different reversal drugs worked. While one drug, atipamezole, was effective on its own in helping the cats wake up, combinations of atipamezole with other drugs showed even better results. However, the most effective combination also caused some side effects like increased heart rate and muscle tremors. Overall, atipamezole is a good choice for reversing anesthesia in cats, but the combination with other drugs may not be the best option due to those side effects.
People also search for: cat anesthesia recovery · atipamezole for cats · cat anesthesia side effects
Abstract
Antagonistic effects of atipamezole (ATI), flumazenil (FLU) and 4-aminopyridine (4AP) alone and in various combinations after administration of medetomidine-midazolam-ketamine (MED-MID-KET) were evaluated in cats. Animals were anaesthetised with MED (50 microg/kg), MID (0.5 mg/kg) and KET (10 mg/kg) given intramuscularly. Twenty minutes later, physiological saline, ATI (200 microg/kg), FLU (0.1 mg/kg), 4AP (0.5 mg/kg), ATI-FLU, FLU-4AP, ATI-4AP or ATI-FLU-4AP was administered intravenously. FLU, 4AP alone, or FLU-4AP did not effectively antagonise the anaesthesia, hypothermia, bradycardia, and bradypnoea induced by MED-MID-KET. ATI alone was effective. ATI-FLU, ATI-4AP and ATI-FLU-4AP combinations produced an immediate and effective recovery from anaesthesia. The combination of ATI-FLU-4AP was the most effective in antagonising the anaesthetic effects, but was associated with tachycardia, tachypnoea, excitement, and muscle tremors. Combinations with ATI are more effective for antagonising anaesthesia, but ATI-FLU-4AP is not suitable.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17766159/