Peer-reviewed veterinary case report
Cat with iris tumor causing blindness and glaucoma treated by eye
By Evans, Paige M et al.·Published in Veterinary ophthalmology·2010·Eye Care for Animals, United States·View original on PubMed →
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Original publication title: Anterior uveal spindle cell tumor in a cat.
- Species:
- cat
Plain-English summary
A 10-year-old female domestic short-haired cat was brought in because of a mass on her iris that was causing her eye to look abnormal. Initially, a fine needle aspiration suggested it was a benign tumor, but after two years, the cat returned with worsening symptoms, including glaucoma and blindness. The veterinarian performed surgery to remove the eye, and tests showed that the tumor was a type of nerve sheath tumor, which is rare in cats. Fortunately, the tumor was not cancerous, and the cat's condition was addressed with the surgery.
People also search for: cat eye mass treatment · glaucoma in cats · cat iris tumor symptoms
Abstract
PURPOSE: To describe a case of anterior uveal spindle cell tumor in a cat with features similar to spindle cell tumor of blue eyed dogs. METHODS: A 10-year-old female spayed domestic short-haired cat was referred for an iris mass OS. The mass was solitary, nodular, nonpigmented, located medially, and causing dyscoria. A diagnosis of a benign epithelial tumor was suggested by a FNA of the mass. The cat was lost to follow-up for 2 years, after which time she re-presented with glaucoma, blindness and grossly evident iridal mass enlargement OS. Transconjunctival enucleation was performed and the globe submitted for histopathology. RESULTS: Histopathology of the enucleated globe revealed the superior iris to be infiltrated and effaced by a large population of neoplastic spindle cells. The cells were arranged in streams and bundles and exhibited Antoni-A and Antoni-B tissue patterns, which are characteristic of Schwann cell tumors. Mitotic figures were rare and cellular pleomorphism moderate. Immunohistochemical staining was positive for S-100 protein and glial fibrillary acidic protein (GFAP), and negative for Melan-A. Interestingly, there was no histological evidence of glaucoma. CONCLUSIONS: Based on its histopathologic characteristics, this iris tumor was diagnosed as a Schwann cell variant of a peripheral nerve sheath tumor (PNST) closely resembling the spindle cell tumor of blue-eyed dogs. Anterior uveal PNST has not been previously reported in cats to the authors' knowledge. The presence of Antoni type A and type B tissue patterns along with immunohistochemical staining may facilitate a diagnosis of PNST and rule out malignant melanoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21182724/