Peer-reviewed veterinary case report
Nitazoxanide treatment kills Toxocara canis worms in infected dogs
By Yuan, Yanyang et al.·Published in Parasitology research·2024·College of Veterinary Medicine, China·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Anthelmintic efficacy of nitazoxanide in dogs naturally infected with Toxocara canis.
- Species:
- dog
Plain-English summary
A group of dogs infected with Toxocara canis, a type of roundworm, were treated with a medication called nitazoxanide to see how well it worked against the worms. After treatment, the number of worm eggs in their feces dropped significantly, with one group showing a 100% reduction in eggs and 90% of the dogs clearing out the remaining worms within a week. The treatment was effective at a dose of 150 mg/kg, showing that nitazoxanide could be a strong option for treating this infection in dogs.
People also search for: dog roundworm treatment · Toxocara canis symptoms in dogs · nitazoxanide for dogs
Abstract
Toxocara canis (T. canis) is a gastrointestinal nematode in dogs, and its larvae also infect humans, causing severe larval migratory disease. Anthelmintic drugs have become the primary means to combat T. canis. In this study, the efficacy of nitazoxanide (NTZ) was tested against all the internal stages of T. canis, including L3 larval stage in vitro experiments and gastrointestinal worm in vivo experiments. In the in vitro experiment, after treatment with NTZ at 7.81 and 62.5 μg/mL for 12 h, the larval mortality efficacy reached 90.0 and 100.0%, respectively. In the in vivo experiments, 100 mg/kg NTZ possessed good anthelmintic efficacy against T. canis, with an egg per gram (EPG) reduction of 99.19%, and 90.00% of dogs cleared with residual worms. These results were comparable to those of the positive control drug. The highest anthelmintic efficacy was observed in the group treated with 150 mg/kg NTZ. Based on faecal egg counts, the number of T. canis eggs decreased by 100.00%, and the percentage of dogs cleared with residual worms achieved 90.00% after 7 days of treatment in the 150-mg/kg NTZ treatment group. In general, NTZ showed great potential to be applied as an anthelmintic against T. canis.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38492070/