Peer-reviewed veterinary case report
New ways to treat pet parasites and prevent resistance
By Martin, Richard J et al.·Published in Veterinary parasitology·2015·Department of Biomedical Sciences, United States·View original on PubMed →
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Original publication title: Anthelmintics: The best way to predict the future is to create it.
Plain-English summary
This research discusses new findings about medications used to control parasites in pets. It highlights how certain drugs, like emodepside and diethylcarbamazine, work together to improve their effectiveness and potentially slow down the development of resistance to these treatments. Emodepside helps to inhibit movement in parasites, while diethylcarbamazine enhances this effect. Another drug, tribendimidine, works differently and may still be effective even when some parasites resist other treatments. Overall, the study suggests that understanding how these drugs work can help create better combinations for treating parasitic infections in pets.
Abstract
'The best way to predict the future is to create it.' When we look at drugs that are used to control parasites, we see that new knowledge has been created (discovered) about their modes of action. This knowledge will allow us to predict combinations of drugs which can be used together rationally to increase the spectrum of action and to slow the development of anthelmintic resistance. In this paper we comment on some recent observations of ours on the modes of action of emodepside, diethylcarbamazine and tribendimidine. Emodepside increases the activation of a SLO-1 K(+) current inhibiting movement, and diethylcarbamazine has a synergistic effect on the effect of emodepside on the SLO-1 K(+) current, increasing the size of the response. The combination may be considered for further testing for therapeutic use. Tribendimidine is a selective cholinergic nematode B-subtype nAChR agonist, producing muscle depolarization and contraction. It has different subtype selectivity to levamisole and may be effective in the presence of some types of levamisole resistance. The new information about the modes of action may aid the design of rational drug combinations designed to slow the development of resistance or increase the spectrum of action.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26138153/